近年研究主題

  1. 異種雜交雄性子代不孕的分子遺傳學
  2. 性別隔離的行為分析
  3. 同種精子競爭優勢的遺傳基
  4. 擬黃果蠅的族群基因學

研究室簡介

我們的研究是想要回答演化生物學中一個基礎的問題—是什麼樣的遺傳變異造成近源種間的表型差異。在近源種中,不論是基因型或表型的改變都已被詳細研究,但兩者之間的連結並不清楚。要研究物種分化期間所累積的遺傳變異,其中一個方法是去研究造成生殖隔離(例如近源種間的棲地改變、生殖前隔離等等)的遺傳機制。我們主要的研究目標是利用遺傳學的方法,建立物種分歧期間基因型和表型改變之間的連結。

近年研究主題

    My research is motivated by a desire to answer one of the fundamental questions in evolutionary biology – the genetic changes that underlie phenotypic differences between closely related species. Both genetic and phenotypic changes between closely related species have been well documented. Yet, the connection between the two is little known. One way to unveil the genetic changes accumulated during species differentiation is to study the genetics of individual traits that contribute to any form of reproductive isolation, such as habitat shift, premating isolation, etc., between closely related species. The main goal of my research is to bridge genotypic and phenotypic changes that occur during species divergence by means of genetic approaches.

代表著作

Publications

Journal
  1. Lu, X., Shapiro, J.A., Ting, C.-T., Li, Y., Li, C., Xu, J., Huang, H., Cheng, Y.-J., Greenberg, A.J., Li, S.-H., Wu, M.-L., Shen, Y., Wu, C.-I.(2010) Genome-wide misexpression of X-linked versus autosomal genes associated with hybrid male sterility. Genome Research, 20 (8), pp. 1097-1102.
  2. Fang, S., Ting, C.-T., Lee, C.-R., Chu, K.-H., Wang, C.-C., Tsaur, S.-C.(2009) Molecular evolution and functional diversification of fatty acid desaturases after recurrent gene duplication in drosophila. Molecular Biology and Evolution, 26 (7), pp. 1447-1456.
  3. Sun, S., Ting, C.-T., Wu, C.-I.(2004) The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Science, 305 (5680), pp. 81-83.
  4. Wu, C.-I., Ting, C.-T.(2004) Genes and speciation. Nature Reviews Genetics, 5 (2), pp. 114-122.
  5. Ting, C.-T., Tsaur, S.-C., Sun, S., Browne, W.E., Chen, Y.-C., Patel, N.H., Wu, C.-I.(2004) Gene duplication and speciation in Drosophila: Evidence from the Odysseus locus. Proceedings of the National Academy of Sciences of the United States of America, 101 (33), pp. 12232-12235.
  6. Takahashi, A., Ting, C.-T.(2004) Genetic basis of sexual isolation in Drosophila melanogaster. Genetica, 120 (1-3), pp. 273-284.
  7. Ting, C.-T., Takahashi, A., Wu, C.-I.(2001) Incipient speciation by sexual isolation in Drosophila: Concurrent evolution at multiple loci. Proceedings of the National Academy of Sciences of the United States of America, 98 (12), pp. 6709-6713.
  8. Tsaur, S.-C., Ting, C.-T., Wu, C.-I.(2001) Sex in Drosophila mauritiana: A very high level of amino acid polymorphism in a male reproductive protein gene, Acp26Aa. Molecular Biology and Evolution, 18 (1), pp. 22-26.
  9. Ting, C.-T., Tsaur, S.-C., Wu, C.-I.(2000) The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus. Proceedings of the National Academy of Sciences of the United States of America, 97 (10), pp. 5313-5316.
  10. Ting, C.-T., Tsaur, S.-C., Wu, M.-L., Wu, C.-I.(1998) A rapidly evolving homeobox at the site of a hybrid sterility gene. Science, 282 (5393), pp. 1501-1504.
  11. Tsaur, S.-C., Ting, C.-T., Wu, C.-I.(1998) Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism. Molecular Biology and Evolution, 15 (8), pp. 1040-1046.
  12. Hollocher, H., Ting, C.-T., Wu, M.-L., Wu, C.-I.(1997) Incipient speciation by sexual isolation in Drosophila melanogaster: Extensive genetic divergence without reinforcement. Genetics, 147 (3), pp. 1191-1201.
  13. Hollocher, H., Ting, C.-T., Pollack, F., Wu, C.-I.(1997) Incipient speciation by sexual isolation in Drosophila melanogaster: Variation in mating preference and correlation between sexes. Evolution, 51 (4), pp. 1175-1181.
  14. Chang H, Ting CT, Lin FJ,(1994) ``On the low genetic variability in Drosophila immigrans and D. formosana.``, Zoological Studies., 33 , 4 , 287 -295 , 10, 1994

學術榮譽

Award

  1. 中央研究院年輕著作獎, 2006.
  2. 清華大學新進人員研究獎, 2005.
  3. 吳大猷紀念獎, 2004.
  4. 國科會甲等獎助, 2000.

開設課程

  • 演化生物學、分子演化、族群遺傳學
  • 遺傳學
  • 分子演化
  • 族群遺傳學