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>首頁 >師資陣容 >陳瑞芬 助理教授 (Ruei-Feng Chen, Assistant Professor)
陳瑞芬 助理教授 (Ruei-Feng Chen, Assistant Professor)
 
職 稱 助理教授
最高學歷 國立台灣大學博士
專 長 神經生理、循環生理
E-mail rfchen@ntu.edu.tw
研究室 神經生理研究室
地  址 生命科學館721 室
電  話 02-33662503
近年研究主題

1. 大鼠心臟迷走神經元之中樞連結與功能調控

2. 大鼠延腦循環呼吸調控神經元活性之記錄與分析

3. 大鼠交感神經活性與血壓、心率變異之相關性

研究室簡介:

  本實驗室主要從事大鼠心臟血管系統之神經控制機轉之探討。以組織化學染色法、正向或逆向追蹤法,或以電刺激、化學刺激興奮神經細胞、電生理記錄自主神經活性或量測心臟血管機能變化(血壓、心電圖、橫膈肌電圖)等技術,來檢查腦中控制心臟血管系統的神經網路。這方面的研究過去曾探討貓及大鼠心臟神經節細胞的分佈、延腦中控制心臟的迷走神經元的分佈及功能之比較,延腦幾個核區(如吻端腹側核區、孤獨核等)對心臟迷走神經元管制之探討等工作,目前正在進行大鼠延腦心臟血管交感性神經元活性之多通道紀錄與分析。

        與台大動物所嚴震東教授、宜蘭大學蔡孟利教授合作進行高血壓發展過程中神經性因素之研究,以頻譜分析(power spectral analysis)的方法進行大鼠交感神經活性與血壓、心率變異相關性之研究,同時亦從事高血壓大鼠感壓反射效益減弱機轉之探討等研究工作。

  與宜蘭大學蔡孟利教授合作,進行過動症模式動物活動為與其心性之關聯性研究。

代表著作

A)學術期刊論文

1.         Chen, R.-F., Tseng, W.-T., Yen, C.-T. and M.-L. Tsai (2006) Frequency response characteristic of sympathetic mediated low-frequency blood pressure fluctuations in conscious rats. Auton. Neurosci.: Basic & Clin.128:48-52.

2.         Fu, H. Y., S. J. Chen, R. F. Chen, W. H. Ding, L. L. Kuo-Huang and R. N. Huang (2006) Identification of oxalic acid and tartaric acid as major persistent pain-inducing toxins in the stinging hairs of the nettle, Urtica thunbergiana. Annals of Botany 98:57-65.

3.     Shaw, F.-Z., C.-T., Yen and R.-F. Chen (2003) A simple and effective process for noise reduction of multichannel cortical field potential recordings in freely moving rats. J. Neurosci. Methods 124:167-174.

4.     Shaw, F.-Z., C.-T. Yen and R.-F. Chen (2002) Neural and cardiac activities are altered by injection of picomoles of glutamate into the nucleus ambiguus of the rat Chinese J. Physiol.45 (2):57-62.

5.     Shaw, F.-Z., C.-T. Yen and R.-F. Chen (2001) Construction of a recording-injection microelectrode with microwire. Acta Zoologica Taiwanica 12(1):21-30.

6.     Shaw, F.-Z., R.-F. Chen and C.-T. Yen (2001) Dynamic changes of touch- and laser heat-evoked field potentials of primary somatosensory cortex in awake and pentobarbital-anesthetized rats. Brain Res. 911:105-115.

B)學術研討會論文

1.      W.-T. Tseng, M.-L. Tsai, C.-T. Yen and R.-F. Chen (2006) Different contribution of three types of rostral ventrolateral medullary neurons in the generation of slow sympathetic oscillations. 36th Annual Meeting, Soc. Neuronsci. Abst. (SCI)

2.      Lu, Y. F., K. J. Weaver, R. F. Chen, R. C. Lin, K. L. Simpson (2006) Differential expression of serotonin and nitric oxide in dorsal raphe projections to locus coeruleus and medial prefrontal cortex. 36th Annual Meeting, Soc. Neuronsci. Abst. (SCI)

3.      Chen, R.-F., W.-T. Zeng , C.-T. Yen and M.-L. Tsai (2005) Quantitative relationship between fluctuations of blood pressure and sympathetic nerve activity in freely moving rats. 35th Annual Meeting, Soc. Neuronsci. Abst. (SCI)

4.      Lo, Y.-L. and R.-F. Chen (2005) Study of cardiac related neuron in nucleus ambiguous of rats. The 20th Joint Annual Conference of Biomedical Sciences.

5.      Chen, R.-F., W.-T. Zeng and M.-L. Tsai (2005) Does low frequency fluctuation of blood pressure index sympathetic tone? The 20th Joint Annual Conference of Biomedical Sciences.

6.      Chen, R.-F., C.-T. Yen and F.-Z. Shaw (2003) A simple and effective process for noise reduction of multichannel cortical field potential recordings in freely moving rats. The 18th Joint Annual Conference of Biomedical Sciences.

7.      Chen, R.F., P.F. Yang, J.H. Hsieh and C.T. Yen (2002) Vagal control of heart rate and ventricular contractility in turtles. 32th Annual Meeting, Soc. Neuronsci. Abst. (SCI)

8.      Wang, T.Y., D.E. Haines, R.-F. Chen, K.L. Simpsom and R.C.S. Lin (2002) Patterning of axon terminals within zona incerta from the spinal trigeminal nucleus: a light microscopic study. 32th Annual Meeting, Soc. Neuronsci. Abst. (SCI)

9.      Chen, R.-F., C.-T. Yen and F.-Z. Shaw (2002) Neural and cardiac activities are altered by injection of picomoles of glutamate into the nucleus ambiguus of the rat  The 17th Joint Annual Conference of Biomedical Sciences.

10.   Yang, P.F., J.H, Hsieh, R.-F. Chen and C,-T. Yen (2001) Functional and histological studies of the turtle cardiac vagal nerve. The 16th Joint Annual Conference of Biomedical Sciences.

11.   Shaw, F.-Z., R.-F. Chen and C.-T. Yen  (2001) Dynamic Changes of Touch- and Laser Heat-evoked Field Potentials of Primary Somatosensory Cortex in Awake and Pentobarbital-anesthetized Rats. The 16th Joint Annual Conference of Biomedical Sciences.

12.   Shaw, F.-Z., R.-F. Chen, K.L. Simpson and R.C.S. Lin (2001) Functional Characteristics of the Ensemble Neuronal Activity of Zona Incerta in Freely Moving Rats. The 16th Joint Annual Conference of Biomedical Sciences.

開設課程
B01 32310 動物生理學
B01 32320 動物生理學實驗
B01 101A2 普通生物學
B01 101B0 普通生物學
B01 106A2 普通生物學實驗
B01 10700 普通動物學實驗
B01 49100 專題研究
B01 40010 書報討論
P01 U1230 生物科教材教法
B41 U1020 循環生理學
B41 M0430 循環生理專題討論
B41 M0320 神經生理學專題討論
B41 U0200 生物學教學實習
B41 M1060 神經生物學技術
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